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Journal of Pharmacology And Experimental Therapeutics, Vol. 97, Issue 2, 182-190, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE ADDICTION LIABILITY OF SOME DERIVATIVES OF MEPERIDINE

HARRIS ISBELL 1

1 Research Division, U. S. Public Health Service Hospital, Lexington, Kentucky

In sufficient dose, bemidone, keto-bemidone, Nu-1196, Nu-1779, and Nu-1932 induce morphine-like euphoria in former morphine addicts, and relieve abstinence from morphine. All these compounds must be regarded as addictive.

Volunteers experimentally addicted to keto-bemidone exhibited morphine-like regressive behavior and developed tolerance to a number of actions of the drug. Following withdrawal of keto-bemidone, an abstinence syndrome, qualitatively similar to abstinence from morphine but quantitatively more severe, appeared very rapidly.Keto-bemidonehas very great addiction liability.

Submitted on June 30, 1949






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.