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Journal of Pharmacology And Experimental Therapeutics, Vol. 97, Issue 2, 144-149, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

ISCHEMIC STRIATED MUSCLE AS AN INDICATOR OF THE ACTIVITY OF A CARDIAC GLYCOSIDE

E. C. del POZO 1 and E. G. PARDO 1

1 Department of Pharmacology and Physiology, Institute of Health and Tropical Diseases, México, D. F.

A study was made of the effects of k-strophanthoside on the contractions of the gastrocnemius-soleus-plantaris muscles made ischemic by intermittent occlusion of the aorta in cats anesthetized with Dial.

The intravenous injection of 0.1 to 0.2 mgm. per kgm. of k-strophanthoside was followed by changes in the responses to direct and to indirect stimuli. The amplitude of the contractions became greater, the duration shorter, and relaxation more complete.

The probable relations of these effects to the actions of digitalis glycosides on the failing heart are discussed, as is also the possibility of using ischemic striated muscle as an indicator of non-toxic digitalis actions.

Submitted on June 6, 1949






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.