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Journal of Pharmacology And Experimental Therapeutics, Vol. 97, Issue 2, 140-143, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE PROLONGATION OF PENTOBARBITAL SODIUM ANESTHESIA BY NITRATES AND NITRITES

HAROLD A. WOOSTER JR. 1 and F. WILLIAM SUNDERMAN 1

1 Mellon Institute, Pittsburgh, Pa.; University of Texas Postgraduate School of Medicine; M. D. Anderson Hospital, Houston, Texas

The recovery time of white mice anesthetized with pentobarbital sodium is significantly prolonged by the intraperitoneal injection of nitroglycerine, butyl nitrate, diethyleneglycol dinitrate or sodium nitrite. Nitroglycerine appears to be the most effective of the compounds studied. The dosages required to demonstrate this phenomenon are of the order of 20 to 50 mgm./kgm. of body weight.

Significant prolongation of recovery time may also be produced by the inhalation for twenty minutes of butyl nitrate in concentrations of 30 to 45 mgm./liter.

Submitted on June 2, 1949






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.