THE COMPARATIVE PRESSOR ACTIVITY OF THE OPTICAL ISOMERS OF CYCLOHEXYLISOPROPYLAMINE AND CYCLOHEXYLISOPROPYLMETHYLAMINE

¹ Department of Pharmacology, West Virginia University School of Medicine, Morgantown

d-Amphetamine sulfate is more active than l-amphetamine sulfate in raising the blood pressure of barbitalized and unanesthetized dogs. Both of these isomers are more active than the corresponding desoxyephedrine hydrochlorides, although d-desoxyephedrine is more active than l. Conversely, l-cyclohexylisopropylamine hydrochloride is more active than d, and they both are slightly less active than the corresponding amphetamine isomers. The cyclohexylisopropylmethylamine hydrochlorides are the least active of all, although the l isomer is more active than the d isomer.

On oral administration in man, d-amphetamine sulfate is the most active agent in this group in raising the blood pressure, with the l isomer of amphetamine and d-desoxyephedrine about one-half as active, l-desoxyephedrine about one-third, the cyclohexylisopropylamines one-sixth to one-eighth, and the cyclohexylisopropylmethylamines only one-eighth to one-tenth as active. The amphetamine and desoxyephedrine isomers produce obvious central nervous system stimulation in man while the cyclohexylisopropyl and cyclohexylisopropylmethylamines do not.