JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Millican, R. C.
Right arrow Articles by Tabor, H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Millican, R. C.
Right arrow Articles by Tabor, H.
Journal of Pharmacology And Experimental Therapeutics, Vol. 97, Issue 1, 4-13, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

ON THE METABOLISM OF HISTAMINE. A. URINARY EXCRETION FOLLOWING ORAL ADMINISTRATION. B. CONJUGATION IN VITRO

R. Carl Millican 1, Sanford M. Rosenthal 1, and Herbert Tabor 1

1 Experimental Biology and Medicine Institute, National Institutes of Health, Bethesda, Maryland

The excretion of free and conjugated histamine in the urine has been determined after oral administration to mice, rats, rabbits, guinea pigs, and dogs. In mice and rats up to 37 per cent of the administered dose could be recovered largely in the free form. In the other species from 3 to 20 per cent was recovered chiefly as conjugated histamine.

Rabbit and pigeon liver slices in vitro were capable of conjugation of histamine. Conjugation was also obtained with a cell free extract prepared from an acetone powder of pigeon liver; with this preparation it was shown that coenzyme A is required for the process.

Submitted on May 14, 1949






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.