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1 Department of Pharmacology, West Virginia University School of Medicine, Morgantown
N-Methylberbamine iodide and N-methylisotetrandine iodide were compared with d-tubocurarine chloride pentahydrate and d-O-methyltubocurarine iodide in rats, rabbits, cats, dogs, and man. N-Methylberbamine is approximately as active a paralyzing agent as d-tubocurarine, but differs in that it possesses fewer secondary effects. N-Methylisotetrandine, the O-methyl ether of N-methylberbamine, is less active than d-tubocurarine and much less active than d-O-methyltubocurarine, the most active agent of the group.
Submitted on May 14, 1949