JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Way, E. L.
Right arrow Articles by Ellsworth, H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Way, E. L.
Right arrow Articles by Ellsworth, H.
Journal of Pharmacology And Experimental Therapeutics, Vol. 96, Issue 4, 477-484, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE ABSORPTION, DISTRIBUTION AND EXCRETION OF ISONIPECAINE (DEMEROL)

E. Leong Way 1, Abraham I. Gimble 2, William P. McKelway 2, Helen Ross 2, Chen-Yu Sung 2, and Homer Ellsworth 2

1 University of California, College of Pharmacy and Division of Pharmacology, School of Medicine, San Francisco, Calfornia.
2 Department of Pharmacology and the Department of Obstetrics, The George Washington University, School of Medicine, Washington, D. C.

1. After administration of isonipecaine (Demerol) to rats the compound concentrates mainly in the kidneys, spleen, lungs and liver. Appreciable levels are attained in the brain and lower concentrations in heart and muscle.

2. After repeated administration of isonipecaine three times daily for several days virtually no isonipecaine could be recovered from the animals 24 hours later.

3. Isonipecaine is rapidly and almost totally absorbed after oral administration.

4. Isonipecaine or its metabolite(s) is excreted to some extent in saliva; but no isonipecaine was detected in the milk of individuals receiving the compound.

5. Less than 5 per cent of the total oral isonipecaine dosage was separated and characterized from urine by countercurrent techniques.

6. An even smaller amount of isonipecaine (less than one per cent) was found in the urine of newborns whose mothers had previously received isonipecaine during the first stage of delivery.

Submitted on May 31, 1949






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.