FURTHER PHARMACOLOGIC CHARACTERIZATION OF THE SYMPATHOMIMETIC, ALIPHATIC AMINE 2 METHYLAMINO- 6-HYDROXY-6-METHYL HEPTANE

¹ Department of Pharmacology, Medical College of South Carolina, Charleston, S. C.

2 Methylamino-6-hydroxy-6-methyl heptane was found to be of a low order of chronic toxicity and to be without important species differences with regard to acute toxicity. The LD₅₀ of intravenously injected doses in mice, rabbits and dogs was approximately 350 times greater than the dose which has been described as producing in dogs an approximately 30 per cent increase in contractile force of the heart (10). Acute toxicity appeared to be based chiefly on central nervous system stimulation, although in animals surviving for some hours after large intravenously administered doses, lung consolidation was commonly observed. The drug exhibited weak mydriatic action, relative absence of effect on gut movements recorded with intestinal fistula dogs and relative absence of effects on central nervous system when used in the lower dose range.