JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Walton, R. P.
Right arrow Articles by Brodie, O. J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Walton, R. P.
Right arrow Articles by Brodie, O. J.
Journal of Pharmacology And Experimental Therapeutics, Vol. 96, Issue 4, 343-351, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

CARDIO-VASCULAR EFFECTS OF TWO ALIPHATIC AMINES AND OF EPHEDRINE

Robert P. Walton 1 and Oliver J. Brodie 1

1 Department of Pharmacology, Medical College of South Carolina, Charleston, S. C.

2-Methylamino-6-hydroxy-6-methyl heptane produced in dogs pressor effects and cardiac stimulation when given in doses five to ten times greater than those producing comparable effects with ephedrine. In contrast to ephedrine and 6-methylamino-2-methyl-2-heptene, this compound produced a distinctly lesser degree of cardiac depression when given in large or repeated doses. Similar relations of cardiac depression for these three amines were demonstrated in the isolated rabbit heart, although the distinctions were not so pronounced.

Submitted on February 25, 1949






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.