COMPARATIVE SPASMOLYTIC ACTIVITIES OF CERTAIN BENZHYDRYL ALKAMINE ETHERS AND RELATED COMPOUNDS

¹ Laboratories of Gordon A. Alles, Ph.D., Pasadena, California

1. The anti-histamine activities of a series of ethyl substituted dimethyl-aminoethyl benzhydryl ethers were evaluated and all found to be less active than the unsubstituted dimethylaminoethyl benzhydryl ether (Benadryl).

2. Certain corresponding derivatives of benzhydryl amine and methylamine were also studied and were found to be less active than the oxygen ethers in both their anti-histamine and anti-acetylcholine activities.

3. Dimethylaminoethanol benzhydrylacyl ester and dimethylalkylcarboxyl benzhydrol esters, closely corresponding in molecular size to the more active dimethylaminoalkyl benzhydryl ethers, were studied and found to be less active in their anti-histamine activities, and no more active in their anti-acetyicholine activities.