JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hewitt, R. I.
Right arrow Articles by Subbarow, Y.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Hewitt, R. I.
Right arrow Articles by Subbarow, Y.
Journal of Pharmacology And Experimental Therapeutics, Vol. 96, Issue 3, 305-314, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

EXPERIMENTAL CHEMOTHERAPY OF TRYPANOSOMIASIS

I. Effect of p-Phenylene Diguanidine and Related Compounds Against Experimental Infections with Trypanosoma equiperdum

R. I. Hewitt 1, A. Gumble 1, S. Kushner 1, S. R. Safir 1, L. M. Brancone 1, and Y. Subbarow 1

1 Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York

Data are given which demonstrate the trypanocidal activity of p-phenylene diguanidine and related derivatives against Trypanosoma equiperdum in mice. This compound is much less effective when administered parenterally than arsenicals and other known trypanocides such as Bayer 205 or Stilbamidine. It is effective when administered in multiple doses orally, however, and for this reason is considered to be of potential interest for trial in man or domestic animals. Of the related guanidines tested none showed markedly greater activity or were better tolerated than p-phenylene diguanidine.

Submitted on April 4, 1949






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.