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Journal of Pharmacology And Experimental Therapeutics, Vol. 96, Issue 3, 295-304, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

ON THE ANTAGONISM BETWEEN PRESSOR AND DEPRESSOR AGENTS IN THE FROG'S HEART

Otto Loewi 1

1 Department of Pharmacology, New York University College of Medicine, New York

1) During depression of the amplitude of the heartbeats by acetylcholine but not by potassium the responsiveness of the heart to the augmentory action of epinephrine and sodium oleate is greatly diminished.

2) The depressor action of acetylcholine and potassium is antagonized by tetraethylammonium. In the case of acetylcholine this antagonism is due to substrate competition.

3) In the normal and in the potassium depressed heart, ATP, ADP and AMP produce an immediate and steep transitory increase of the amplitude of the heartbeats, followed by a gradual rise which slowly fades. The second increase is suppressed during acetylcholine depression.

4) The mechanism involved in these actions is discussed.

Submitted on March 29, 1949






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.