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Journal of Pharmacology And Experimental Therapeutics, Vol. 96, Issue 3, 250-257, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE FATE OF TWO ARSENOXIDES IN THE DOG

Thomas H. Maren 1

1 Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University, Baltimore, Md.

1. A colorimetric method for the determination of o-aminophenols has been described. This has been applied to plasma and urine to determine the o-amino-phenol component after the administration of oxophenarsine to dogs. Parallel determinations of the arsenic content were performed.

2. Oxophenarsine was found to be relatively unstable in the dog, existing as such for only three to six hours.

3. Similar studies were carried out for m-amino-p-carbamylphenylarsenoxide, using determinations of arylamino group and arsenic. The results suggest that this compound is relatively stable, and may circulate as such for 12-24 hours.

Submitted on March 21, 1949






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