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Journal of Pharmacology And Experimental Therapeutics, Vol. 96, Issue 3, 228-237, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

VASO- AND BRONCHODILATOR EFFECTS OF N-ISOPROPYL-NOREPINEPHRINE IN ISOLATED PERFUSED DOG LUNGS

C. O. Hebb 1 and H. Konzett 1

1 Department of Physiology, Edinburgh University

1) In isolated, blood-perfused dog lungs, with either negative or positive pressure ventilation, N-isopropyl-norepinephrine causes pulmonary vasodilatation. Such responses are obtained when the drug is administered by intravascular injection or by inhalation of a spray.

2) Cocaine, atropine, pilocarpine or ergotoxine (and related compounds) do not alter the direction of the response.

3) Under all of the conditions of experimentation employed here, N-isopropyl-norepinephrine has a strong bronchodilator action, its activity usually being ten times greater than that of epinephrine.

Submitted on February 28, 1949






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