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Journal of Pharmacology And Experimental Therapeutics, Vol. 96, Issue 2, 188-192, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF A NITROGEN MUSTARD ON CERTAIN SYNTHETIC REACTIONS IN VITRO

GORDON R. McKINNEY 1

1 Department of Physiology and Pharmacology, Duke University School of Medicine, Durham, North Carolina

1. Inhibition of the conjugation of morphine and glucuronic acid, of phenol and sulfuric acid, and of p-aminobenzoic acid and glycine, and of urea synthesis by methyl-bis-(beta-chloroethyl)-amine HCl (MBA) is described.

2. Variations of the sensitivities of these reactions to the same concentration of MBA were found.

3. None of the compounds tested increased the amount of morphine conjugated, nor did any with the exception of protein overcome the MBA inhibition. Protein in the reaction mixture offered partial protection.

4. MBA inhibits the conjugation of morphine in concentrations which have little effect on respiration.

Submitted on February 19, 1949






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.