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Journal of Pharmacology And Experimental Therapeutics, Vol. 96, Issue 2, 139-144, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF LIVER DAMAGE ON THE ACTIVITY OF G-STROPHANTHIN IN THE RAT

A. FARAH 1 and E. SMUSKOWICZ 1

1 Departments of Pharmacology, University of Washington Medical School, Seattle; American University of Beirut, Beirut, Lebanon

In the rat surgical hepatectomy (evisceration) reduces the lethal dose and elimination of g-strophanthin. Exclusion of the kidney has no detectable effects on the lethal dose of this glycoside.

Carbon tetrachloride and phosphorus poisoning produces a reduction in the lethal dose of g-strophanthin. This reduction is due to the reduced excretion of g-strophanthin by the liver and to an increase in the sensitivity of the rat heart to g-strophanthin.

Submitted on January 31, 1949






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.