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Journal of Pharmacology And Experimental Therapeutics, Vol. 96, Issue 1, 95-98, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE FAILURE OF 2,3 DITHIOPROPANOL (BAL) TO AFFECT ACUTE, SYSTEMIC URANIUM POISONING

W. F. Neuman 1 and R. P. Allen 1

1 Division of Pharmacology and Toxicology of Department of Radiation Biology, Univercity of Rochester School of Medicine and Dentistry, Rochester, New York

1. Albino rats were systemically poisoned with 3.0 mgm./kgm. of HgCl2 I.P., and successfully treated with BAL as late as 30 minutes after the administration of Hg.

2. Studies were made of the effect of BAL on the toxic effects of three uranium compounds (UO2(NO3)2·6H2O, UO2F2 and UCl4) parenterally administered to albino rats with negative results.

3. The negative results were taken as confirmatory evidence for the view that uranium exerts its toxic effects primarily by some other means than a combination with —SH groups.

Submitted on January 27, 1949






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.