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Journal of Pharmacology And Experimental Therapeutics, Vol. 96, Issue 1, 38-41, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE GANGLIONIC BLOCKING ACTION OF "DIBUTOLINE"

Carl C. Gruhzit 1 and Gordon K. Moe 1

1 Department of Pharmacology, University of Michigan, Ann Arbor

Dibutoline, in addition to its atropine-like action, produces effects comparable with those of tetraethylammonium: (1) fall of heart rate and blood pressure with increased femoral blood flow; (2) abolition of the pressor response to carotid occlusion; (3) suppression of the pressor actions of nicotine and acetylcholine; (4) potentiation of the pressor effects of epinephrine. These actions were shown to be due to blockade of ganglionic transmission.

Submitted on January 12, 1949






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.