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Journal of Pharmacology And Experimental Therapeutics, Vol. 96, Issue 1, 1-10, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE ANTISPASMODIC ACTION OF BASIC NITRILES

A. M. Lands 1, Estelle Ananenko 1, Gwendolyn Jones 1, James O. Hoppe 1, and T. J. Becker 1

1 Biology Division, Sterling-Winthrop Research Institute, Rensselaer, New York

1. The methiodide salts of various diphenylaminoalkanenitriles have significant anticholinergic activity.

2. The nitrite group appears to be important for this anticholinergic action.

3. The most active quaternary salts in this group of compounds are effective antispasmodics when administered parenterally, sublingually or orally.

4. Acute intravenous toxicity of these quaternary salts in albino mice is relatively high; by contrast oral toxicity of two of these is low.

Submitted on December 17, 1948






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