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Journal of Pharmacology And Experimental Therapeutics, Vol. 95, Issue 4, 502-505, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

AN INVESTIGATION OF THE ACUTE TOXICITY OF THE OPTICAL ISOMERS OF ARTERENOL AND EPINEPHRINE

JAMES O. HOPPE 1, D. K. SEPPELIN 1, and A. M. LANDS 1

1 Biology Division of the Sterling-Winthrop Research Institute, Rensselaer, New York

1. Toxicity ratios for the levo, dextro and racemic forms of arterenol were found to be 1:14:1.3 in rats and 1:12:1.5 in mice by intravenous injection.

2. Toxicity ratios for the levo, dextro and racemic forms of epinephrine were found to be 1:20:1.8 in rats and 1:18.5:1.5 in mice by intravenous injection.

3. Rats were 50 times as sensitive to arterenol and 60 times as sensitive to epinephrine as mice when judged by the acute lethal doses.

4. The three optical forms of epinephrine were approximately twice as toxic as the corresponding forms of arterenol.

5. l-Epinephrine was significantly more toxic than the racemic mixture whereas no significant difference was found between l-and dl-arterenol in either rats or mice.

6. The dose-mortality curves were very steep in rats for arterenol and epinephrine and in mice for l, and d, l-epinephrine. However, they were flat in mice for d-epinephrine and arterenol.

Submitted on January 4, 1949




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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.