ADRENERGIC BLOCKING DRUGS. IV. ANTAGONISM OF EPINEPH RINE AND HISTAMINE WITH 2-(2-BIPHENYLOXY)-2-CHLORODIETHYLAMINE DERIVATIVES

¹ Department of Pharmacology, University of Illinois, College of Medicine, Chicago 12

2-(2-Biphenylyloxy)-2-chlorodiethylamines with N-substituted alkyl and 2-chloroethyl groups exerted a moderate degree of adrenergic blocking action in mice and dogs and diminished the depressor action of histamine in dogs. The lower alkyl homologues weakly antagonized the bronchioconstrictive action of histamine in guinea pigs. In dogs, depressor responses to acetylcholine were not significantly diminished. The properties of these compounds are briefly compared and contrasted to those possessed by other 2-halogenated ethylamines.