THE ALTERED BLOOD-PRESSURE RESPONSE AFTER ADRENOLYTIC DRUGS AND LARGE DOSES OF SYMPATHOMIMETIC AMINES

¹ Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York

After an adrenolytic drug, the depressor response to epinephrine can be temporarily transformed into a pressor response if a large dose of a sympathetic depressor amine such as the isopropyl homologue of epinephrine (Isuprel) or ethylnorepinephrine (Butanephrine) first be given. Simultaneously, there is no vascular response to previously effective doses of the particular depressor amine used. This blocking of depressor responses is termed tapenolysis sympathotapenolysis in a strict sense).

Experiments with other sympathomimetic amines are described. The best tapenolytic agents are Isuprel and Butanephrine. A large dose of epinephrine can be both tapenolytic and adrenolytic. An explanation of tapenolysis is offered.