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Journal of Pharmacology And Experimental Therapeutics, Vol. 95, Issue 3, 407-414, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

CENTRAL IMPAIRMENT OF SYMPATHETIC REFLEXES BY 8-AMINOQUINOLINES

GORDON K. MOE 1, BRAULIO PERALTA 1, and MAURICE H. SEEVERS 1

1 Department of Pharmacology, University of Michigan, Ann Arbor

1. Pamaquine, pentaquine, and isopentaquine chronically administered to dogs produce impairment of sympathetic cardiovascular reflexes, but not of parasympathetic or respiratory reflexes.

2. Pentaquine and isopentaquine, but probably not pamaquine, cause similar effects in the monkey.

3. The impairment of reflexes is believed to be due to destruction of medullary cell-groups.

Submitted on November 24, 1948




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