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Journal of Pharmacology And Experimental Therapeutics, Vol. 95, Issue 3, 360-362, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

REDUCTION AND OXIDATION OF CHLORAL HYDRATE BY ISOLATED TISSUES IN VITRO

THOMAS C. BUTLER 1

1 Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University, Baltimore, Maryland

Measurements have been made of the trichioroethanol and trichloroacetic acid produced from chloral hydrate in vitro by isolated tissue preparations of the dog and of the rat.

All of the tissues studied were capable under aerobic conditions of reducing chloral hydrate to trichloroethanol.

Oxidation of chloral hydrate to trichloroacetic acid was demonstrated only in preparations of liver and kidney of both species.

Submitted on November 15, 1948






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.