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Journal of Pharmacology And Experimental Therapeutics, Vol. 95, Issue 2, 191-200, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

ggr-DICHROINE, THE ANTIMALARIAL ALKALOID OF CH`ANG SHAN

Francis G. Henderson 1, Charles L. Rose 1, Paul N. Harris 1, and K. K. Chen 1

1 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

1. ggr-Dichroine, an alkaloid of Ch`ang Shan, has a Q value of 148 against Plasmodium lophurae in ducklings, and a Q value of 137 against P. relictum in canaries. It is also active against P. cynomolgi in monkeys.

2. ggr-Dichroine in a single dose is approximately 3frac12 times as toxic to mice by mouth than by vein. Repeated administration of ggr-dichroine in mice may result in hydropic degeneration of the liver.

3. ggr-Dichroine induces vomiting in pigeons following intravenous injection, the EmD50 ± S. E. being 0.132 ± 0.04 mgm. per kgm.

4. ggr-Dichroine has no effect on blood pressure and respiration in anesthetized dogs in the dose of 2.5 mgm. per kgm., but slightly lowers blood pressure with an acceleration of the respiratory rate in the dose of 4 mgm. per kgm.

5. ggr-Dichroine stimulates duodenal peristalsis in anesthetized dogs, but inhibits the activity of the isolated rabbit's ileum. It causes diarrhea in nonanesthetized rabbits and rats following intravenous injection.

6. ggr-Dichroine produces hyperglycemia in rabbits in the dose of 2.5 mgm. per kgm. when injected intravenously. In rats, the same dose when given by mouth shows a slightly greater antipyretic action than acetylsalicylic acid.

Submitted on October 27, 1948






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.