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Journal of Pharmacology And Experimental Therapeutics, Vol. 95, Issue 2, 171-176, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

EFFECTS OF TETRAETHYLAMMONIUM BROMIDE ON THE PARASYMPATHETIC NEUROEFFECTOR SYSTEM

J. V. Luco 1 and J. Marconi 1

1 Department of Pharmacology and Biochemistry, Catholic University of Chile

The effect of tetraethylammonium bromide on the parasympathetic ganglion and the postganglionic cholinergic effector system was studied on cats anesthetized with sodium pentobarbital.

During stimulation of the preganglionic fibers of the ciliary ganglion, a blocking of the transmission of tile impulse through the ganglion was observed.

The stimulation of the postganglionic fibers revealed a blocking of the pupillary response with intravenous doses of 10 to 100 mgm. per kilogram of body weight, and a potentiation of the response with doses from two to three times larger.

Submitted on October 21, 1948






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.