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Journal of Pharmacology And Experimental Therapeutics, Vol. 95, Issue 2, 149-154, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

DIATROPINE DERIVATIVES AS PROOF THAT d-TUBOCURARINE IS A BLOCKING MOIETY CONTAINING TWIN ATROPINE-ACETYLCHOLINE PROSTHETIC GROUPS

K. K. Kimura 1, Klaus Unna 1, and Carl C. Pfeiffer 1

1 Department of Pharmacology, University of Illinois College of Medicine, Chicago 12, Ill.

Diatropines, whether synthesized by quaternization through the nitrogen atoms or by connecting the tropic acid hydroxyl groups by an aliphatic chain, have a markedly increased curare-like potency which approaches that of d-tubocurarine. Compounds with slight atropine-like activity become curare-like when two molecules are connected by an alkyl chain of suitable length. When the oxygen prosthetic groups are joined a chain of 9 A length should be used while a chain of 15 A length is probably optimal for joining the nitrogen atoms.

Submitted on October 18, 1948




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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.