JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Watts, D. T.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Watts, D. T.
Journal of Pharmacology And Experimental Therapeutics, Vol. 95, Issue 2, 117-121, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

INHIBITION OF SUCCINIC OXIDASE SYSTEM BY MEPERIDINE, METHADON, MORPHINE AND CODEINE

Daniel T. Watts 1

1 Department of Pharmacology, School of Medicine, University of Virginia, Charlottesville, Va.

Morphine, codeine, meperidine, and methadon inhibit the oxidation of succinate by brain homogenate. Spectrographic data showed these drugs prevent the reduction of cytochrome c by the enzyme preparation and succinate indicating the block occurred at the dehydrogenase or an unknown factor. The inhibition of the oxidation of p-phenylenediamine by methadon shows blockage also occurs at the cytochrome-cytochrome oxidase level.

Submitted on October 13, 1948






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.