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Journal of Pharmacology And Experimental Therapeutics, Vol. 95, Issue 1, 53-57, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

A SIMPLE ASSAY FOR PARASYMPATHOLYTIC AGENTS USING THE LACRIMATION RESPONSE IN RATS

Martin M. Winbury 1, Dorothy M. Schmalgemeier 1, and W. E. Hambourger 1

1 Pharmacology Laboratories, Research Department, G. D. Searle and Co., Chicago

A simple all-or-none assay for parasympatholytic agents using unanesthetized rats is described. The assay is based on the inhibition of lacrimation induced by Mecholyl. Weight, age and sex differences have no apparent influence on the results. Action following various routes of administration can be studied. Examples are given for intraperitoneal and oral routes of administration.

Submitted on September 20, 1948






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.