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Journal of Pharmacology And Experimental Therapeutics, Vol. 95, Issue 1, 45-52, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGICAL PROPERTIES OF THREE NEW ANTIHISTAMINIC DRUGS

A. M. Lands 1, James O. Hoppe 1, O. H. Siegmund 1, and F. P. Luduena 1

1 Biology Division of the Sterling-Winthrop Research Institute, Rensselaer, New York

1. WIN 2848 is a highly active antagonist of histamine and is more potent in its antihistaminic actions than are the chioro- and bromo- substituted analogs, WIN 2875 and WIN 2876.

2. The antihistaminic drugs investigated here stimulate the isolated guinea pig uterus.

3. WIN 2848, in a dose of 0.013 mgm./kgm., protects guinea pigs against 2.8 intravenous lethal doses of histamine.

4. WIN 2848 diminishes the effects of histamine given percutaneously to man.

5. WIN 2848 does not appear to be significantly more toxic than structurally similar antihistaminic drugs.

Submitted on September 17, 1948






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.