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Journal of Pharmacology And Experimental Therapeutics, Vol. 95, Issue 1, 12-17, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE DISTRIBUTION IN RABBIT TISSUES OF INTRAVENOUSLY INJECTED IODINE AS SHOWN BY THE RADIOISOTOPE, I 130

Walter Mann 1, William F. Bale 1, Harold C. Hodge 1, and Stafford L. Warren 1

1 Department of Radiology and Division of Pharmacology and Toxicology, School of Medicine and Dentistry, University of Rochester, Rochester, New York

The distribution of intravenously-administered radioiodine in the tissues of rabbits, up to 12 hours after injection, has been measured; the total iodine present in these tissues has also been determined chemically. The thyroid gland contained relatively high percentages of the injected dose; the other tissues studied, although variations are observed from tissue to tissue, all have a relatively low concentration of radioiodine.

From this work and the data of others, it is concluded that to produce maximal concentrations of radioiodine in the thyroid gland, the total dose of iodine (I 127) should be kept as small as possible.

Submitted on September 15, 1948






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.