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Journal of Pharmacology And Experimental Therapeutics, Vol. 95, Issue 1, 106-115, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF ANESTHETICS ON THE UPTAKE OF RADIOACTIVE PHOSPHORUS BY HUMAN ERYTHROCYTES

V. Pertzoff 1 and C. L. Gemmill 1

1 Department of Pharmacology, Medical School, University of Virginia, Charlottesville, Va.

1. The rate of uptake of radioactive phosphate ions by human erythrocytes is a variable. It varies from individual to individual and in the same individual from day to day. This change seems not to be a function of food intake.

2. Sodium barbital decreases the rate of uptake of radioactive phosphate ions by the red blood cell. Certain quantitative conclusions were derived from experiments covering a large number of individual blood donors.

3. Ether has a retarding effect. Methadon (in very dilute solution) and urethane do not change the rate of uptake of phosphate ions by the red blood cell.

Submitted on October 8, 1948






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.