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Journal of Pharmacology And Experimental Therapeutics, Vol. 95, Issue 1, 100-105, 1949
Copyright © 1949 by American Society for Pharmacology and Experimental Therapeutics

THE CURARIFORM ACTIVITY OF N-METHYLOXYACANTHINE

David F. Marsh 1, D. A. Herring 1, and Clark K. Sleeth 1

1 Departments of Pharmacology and Medicine, West Virginia University School of Medicine, Morgantown, West Virginia

N-Methyloxyacanthine iodide was compared with d-tubocurarine chloride pentahydrate in rats, rabbits, dogs, and man. N-Methyloxyacanthine is about one-half as active a paralyzing agent as d-tubocurarine, but differs in that it also possesses a weak atropine-like action.

Submitted on October 7, 1948






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Copyright © 1949 by the American Society for Pharmacology and Experimental Therapeutics.