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Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 4, 439-443, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

EXPERIMENTAL HEART FAILURE CAUSED BY CENTRAL NERVOUS SYSTEM DEPRESSANTS AND LOCAL ANESTHETICS

ALBERT WOLLENBERGER 1 and OTTO KRAYER 1

1 Department of Pharmacology, Harvard Medical School, Boston

Heart failure was produced in the heart-lung preparation of the dog by the administration of the following compounds: the central nervous system depressants, pentobarbital, chlorobutanol, paraldehyde, propazone, diphenylhydantoin, and trimethadione; and the local anesthetics, cocaine, procaine, and tetracaine. A comparison has been made of the intensity of the negative inotropic cardiac action of these compounds, and other phases of their toxic action on the heart have been described.

Submitted on September 13, 1948






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.