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Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 4, 431-438, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE TOXICITY, DISTRIBUTION AND EXCRETION OF EMETINE

ABRAHAM I. GIMBLE 1, CLARKE DAVISON 1, and PAUL K. SMITH 1

1 Department of Pharmacology, The George Washington University School of Medicine, Washington, D. C.

1. The LD50 of emetine in mice was 62 mgm. per kgm. and in rats, 17 mgm. per kgm.

2. The relative concentrations of emetine in rat and dog tissues were similar and were of the following order: liver > kidney > spleen > lung > brain > heart > skeletal muscle > blood.

3. Emetine was stored in the tissues of mice, rats, and dogs and was very slowly destroyed or excreted.

4. Emetine was not excreted in the urine to any appreciable extent.

Submitted on August 11, 1948






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.