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Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 4, 412-415, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE TRACHEAL CHAIN

II. THE ANAPHYLACTIC GUINEA PIG TRACHEA AND ITS RESPONSE TO ANTIHISTAMINE AND BRONCHODILATOR DRUGS

JULIO C. CASTILLO 1

1 The Wellcome Research Laboratories, Tuckahoe 7, New York

1. Tracheal chains made from guinea pigs sensitized to horse serum respond to relatively low concentrations of the antigen with prompt contractions which are maintained at the same level for a long period of time.

2. These anaphylactic spasms are not relaxed by antihistamine drugs but are relaxed by bronchodilator drugs.

3. The anaphylactic spasm, as produced in the guinea pig trachea, differs from that produced by histamine, not only in its resistance to antihistamine drugs but also in the fact that the anaphylactic spasm cannot be relaxed by washing.

Submitted on August 30, 1948






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.