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Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 4, 359-366, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE FATE OF PROCAINE IN MAN FOLLOWING ITS INTRAVENOUS ADMINISTRATION AND METHODS FOR THE ESTIMATION OF PROCAINE AND DIETHYLAMINOETHANOL

BERNARD B. BRODIE 1, PHILIP A. LIEF 1, and RAYMOND POET 1

1 Research Service, Third (New York University) Medical Division, Goldwater Memorial Hospital; Departments of Biochemistry and Anesthesia, New York University College of Medicine, New York, N. Y.

1. Methods are described for the estimation of procaine and its transformation products in biological fluids and tissues in vivo.

2. The first step in the metabolism of procaine after its intravenous administration to man was shown to be hydrolysis to diethylaminoethanol and p-aminobenzoic acid. The hydrolysis takes place with unusual rapidity. Diethylaminoethanol is further metabolized in large part, but the nature of its transformation is not known.

3. The hydrolysis of procaine occurs mainly in the plasma.

Submitted on August 11, 1948




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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.