JPET Celsis microsomes equal better data

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by STONE, C. A.
Right arrow Articles by LOEW, E. R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by STONE, C. A.
Right arrow Articles by LOEW, E. R.
Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 4, 350-358, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

ADRENERGIC BLOCKING DRUGS: III. EFFECTS OF TWO HALOGENATED ETHYLAMINES ON PRESSOR RESPONSES TO EPINEPHRINE, NICOTINE AND ADRENERGIC NERVOUS REFLEXES

CLEM A. STONE 1 and EARL R. LOEW 1

1 Department of Pharmacology, University of Illinois College of Medicine, Chicago

N-(2-bromoethyl)-N-ethyl-l-naphthalenemethylamine·HBr and N-2-(2-biphenylyloxy)ethyl-N-(2-chloroethyl)butylamine·HCl, in relatively small doses of 1.0 and 5.0 mgm./kgm., intravenously, respectively, have been shown to be active adrenergic blocking compounds by virtue of the ability to reverse the action of epinephrine and to diminish or block the pressor responses to anoxia, carotid occlusion, and small doses of nicotine in dogs. The experimental evidence supports a peripheral adrenergic blocking action.

Submitted on August 2, 1948






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.