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Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 2, 85-96, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

NAPHTHOQUINONE ANTIMALARIALS

XVIII. Metabolic Oxidation Products

LOUIS F. FIESER 1, FREDERIC C. CHANG 1, WILLIAM G. DAUBEN 1, CHARLES HEIDELBERGER 1, HANS HEYMANN 1, and ARNOLD M. SELIGMAN 1

1 Chemical Laboratory, Harvard University, the Surgical Research Laboratory, Beth Israel Hospital, Boston, Department of Surgery, Harvard Medical School

A study of the metabolism of nineteen 2-hydroxy-3-alkyl-1,4-naphthoquinones in human subjects has established that these substances suffer rapid and extensive degradation consisting in oxidation of the hydrocarbon side chain with the production of metabolites that are distinctly more hydrophilic than the compounds administered. Several of the metabolites were isolated and fully identified; they are secondary alcohols, tertiary alcohols, or carboxylic acids.

Submitted on June 7, 1948






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.