THE ABSORPTION AND ELIMINATION OF CARONAMIDE (4'-CARBOXYPHENYLMETHANESULFONANILIDE)

¹ Department of Pharmacology, The Medical Research Division, Sharp and Dohme, Inc., Glenolden, Pennsylvania
² Department of Pharmacology, The Medical Research Division, Sharp and Dohme, Inc., lenolden, Pennsylvania

Caronamide is rapidly and completely absorbed when administered orally to dogs, as judged by the plasma levels and the overall urinary recovery of the drug and its metabolite(s).

After oral or intravenous administration of caronamide to normal dogs or intravenous administration to bilaterally nephrectomized dogs a portion of the drug is metabolized rapidly. About 60 per cent of a dose of the drug administered to normal dogs is excreted, presumably as such. The other 40 per cent is excreted in the form of a metabolite(s) that is more water-soluble than is the parent compound. The distribution of caronamide in the body is of the same order as, but greater than, that for mannitol, whose volume distribution approximates extracellular water.