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Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 2, 136-149, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

FURTHER STUDIES ON THE ANTIFIBRILLATORY ACTION OF CORONARY DILATOR DRUGS

K. I. MELVILLE 1

1 Department of Pharmacology, McGill University, Montreal, Canada

1. In dogs anesthetized with sodium pentobarbital and artificially respired, administrations of ephedrine, amyl nitrite, sodium nitrite and nitroglycerine in suitable doses, can protect the heart against ventricular premature contractions and fibrillation following injections of epinephrine during chloroform inhalations. Under these conditions the pressor response to epinephrine is not prevented by the nitrites and may be added to that of ephedrine.

2. It is also shown that when the blood pressure is being maintained at a high level by continuous intravenous injections of epinephrine, similar chloroform inhalations do not induce fibrillation.

3. These results do not suggest that the pressor response to epinephrine is the initiating factor in this type of fibrillation.

4. It is suggested that the antifibrillatory effects of these agents are due to their coronary dilator actions.

Submitted on June 28, 1948




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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.