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Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 2, 130-135, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

ENZYMIC HYDROLYSIS OF MORPHINE ESTERS

SYDNEY ELLIS 1

1 Department of Physiology and Pharmacology, Duke University School of Medicine, Durham, North Carolina

1. The activities of the plasma and liver of the rabbit on monoacetylmorphine, benzoylcholine and atropine are due to three separate enzymes.

2. The above conclusion is based on the following observations: the relative activities on the three substrates of plasma as compared with liver; the distribution of the various enzymes in the tissues and bloods of other animals; and the differences in sensitivity of the various activities to esterase inhibitors, to heat and to drying with acetone.

3. The hydrolysis of the 3-acetyl group of heroin appears to be a function of tributyrinase, but not of the enzymes which hydrolyze methylbutyrate, acetyl-choline, or acetylsalicylic acid.

Submitted on June 28, 1948




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C. Stormont and Y. Suzuki
Atropinesterase and Cocaiesterase of Rabbit Serum: Localization of the Enzyme Activity in Isozymes
Science, January 9, 1970; 167(3915): 200 - 202.
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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.