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Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 1, 76-77, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT ON THE PAIN THRESHOLD OF N-ACETYL p-AMINOPHENOL, A PRODUCT DERIVED IN THE BODY FROM ACETANILIDE

Frederick B. Flinn 1 and Bernard B. Brodie 1

1 Columbia University and Research Service, Third (NYU) Medical Division, Goldwater Memorial Hospital, Welfare Island, N. Y.

The pain threshold elevation of N-acetyl p-aminophenol, a product derived in the body from acetanilide, was assayed by cutaneous heat-radiation. The results indicated it to be an active analgesic. It is suggested that the action of acetanilide is directed through this derived product.

Submitted on June 9, 1948






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.