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Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 1, 68-75, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

AN ULTRAVIOLET SPECTROPHOTOMETRIC PROCEDURE FOR THE DETERMINATION OF BARBITURATES

Leo R. Goldbaum 1

1 Army Medical Department Research and Graduate School, Army Medical Center, Washington 12, D. C.

1. A simple, rapid, highly specific procedure is described for the determination of barbiturates in blood and tissues based on the characteristic ultraviolet absorption spectra of the malonyl urea ring structure.

2. The method is sensitive to 0.4 mgm. per 100 cc. of blood and 1.0 mgm. per 100 grams of tissue with an error of less than 10 per cent.

3. This procedure is applicable to the clinical, pharmacological, and toxicological investigation of barbiturates in blood and tissue.

Submitted on May 28, 1948




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S. Spector and E. J. Flynn
Barbiturates: Radioimmunoassay
Science, December 3, 1971; 174(4013): 1036 - 1038.
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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.