JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Greenberg, J.
Right arrow Articles by Josephson, E. S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Greenberg, J.
Right arrow Articles by Josephson, E. S.
Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 1, 60-64, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

SYNERGISTIC EFFECT OF CHLORGUANIDE AND SULFADIAZINE AGAINST PLASMODIUM GALLINACEUM IN THE CHICK

Joseph Greenberg 1, Beverly L. Boyd 1, and Edward S. Josephson 1

1 Subdivision on Malaria, Division of Tropical Diseases, National Institute of Health, Bethesda, Maryland

Concurrent administration of chlorguanide and sulfadiazine was examined for prophylactic and suppressive activity against Plasmodium gallinaceum infections in the chick. It was found that the two drugs potentiate one another. The effective dose of chlorguanide could be reduced to one-quarter when combined with 1/32 to 1/64 the effective dose of sulfadiazine. The potentiation could not be accounted for by the concentrations of the drugs in the blood. The toxicity of the two drugs in combination was additive.

Submitted on May 24, 1948






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.