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1 Department of Pharmacology, University of Chicago
1. Following the intravenous injection of digitoxin (1 mgm./kgm.) into rabbits the blood histamine level decreased.
2. Histamine dihydrochloride (1:1,000,000) greatly potentiated the lethal effect of digitoxin (1:40,000) on the isolated hearts of rabbits, cats and guinea pigs. The hearts of rats were resistant under these experimental conditions.
3. Histamine dihydrochloride (1:1,000,000) exerted a diphasic action on the the coronary outflow of isolated hearts. The hearts of cats, guinea pigs and rats exhibited an initial coronary dilatation while a constriction was observed in the case of rabbit hearts.
4. In joint toxicity studies on guinea pigs digitoxin and histamine dihydrochloride acted synergistically in producing death of the animals.
Submitted on May 17, 1948
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