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Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 1, 29-38, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE FATE OF ACETANILIDE IN MAN

Bernard B. Brodie 1 and Julius Axelrod 1

1 Third (New York University) Medical Division, Goldwater Memorial Hospital, and Department of Biochemistry, New York University College of Medicine and Laboratory of Industrial Hygiene, New York, New York

The route of metabolism of acetanilide in man was shown to be as follows: a minor fraction of the drug deacetylates to form aniline; this compound was shown to be the precursor of the substance which oxidizes hemoglobin to methemoglobin; the major fraction of the drug is oxidized to N-acetyl p-aminophenol; this compound is excreted in a conjugated form. The analgesic action of acetanilide is exerted mainly through N-acetyl p-aminophenol which is an active analgesic. The oxidation of acetanilide occurs mainly in the liver.

Submitted on May 11, 1948




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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.