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Journal of Pharmacology And Experimental Therapeutics, Vol. 94, Issue 1, 22-28, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE ESTIMATION OF ACETANILIDE AND ITS METABOLIC PRODUCTS, ANILINE, N-ACETYL p-AMINOPHENOL AND p-AMINOPHENOL (FREE AND TOTAL CONJUGATED) IN BIOLOGICAL FLUIDS AND TISSUES

Bernard B. Brodie 1 and Julius Axelrod 2

1 Third (New York University Medical) Division, Goldwater Memorial Hospital, New York, New York
2 Department of Biochemistry, New York University College of Medicine, and Laboratory of Industrial Hygiene, New York, New York

Methods are described for the determination of acetanilide and its metabolites. The procedure for acetanilide permits estimation of as little as 4 micrograms of the compound, that for aniline as little as 0.25 micrograms, for N-acetyl p-aminophenol and total conjugated p-aminophenol as little as 10 micrograms.

A comparison of the solubility characteristics of the authentic compounds and the apparent compounds extracted from the plasma and urine of subjects receiving acetanilide, indicates that the methods have a high degree of specificity.

Submitted on May 11, 1948




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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.