JPET Introducing ALZET?ew Model 2006 Pump

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Swanson, E. E.
Right arrow Articles by Chen, K. K.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Swanson, E. E.
Right arrow Articles by Chen, K. K.
Journal of Pharmacology And Experimental Therapeutics, Vol. 93, Issue 3, 423-429, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

COMPARISON OF FRESSOR ACTION OF ALICYCLIC DERIVATIVES OF ALIPHATIC AMINES

Edward E. Swanson 1 and K. K. Chen 1

1 Lilly Research Laboratories, Eli Lilly and Company, Indianapolis 6, Indiana

1. A comparison of pressor action of 11 alicyclic ethyl and propyl amines has been made in pithed dogs.

2. The most active compound is 2-methylamino-1-cyclopentyl-propane. It has a long duration of action, and is effective in raising blood pressure in dogs by mouth.

3. 2-Methylamino-1-cyclopentyl-propane has the usual effects of sympathomimetic amines on smooth muscle organs.

4. 2-Methylamino-1-cyclopentyl-propane has an acute toxicity in mice by intravenous injection between that of ephedrine and amphetamine. Continuous administration of this compound in food to rats in concentrations varying from 0.01 to 0.1 per cent for a period of 27 days does not result in pathological changes of visceral organs.

Submitted on April 8, 1948






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.