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Journal of Pharmacology And Experimental Therapeutics, Vol. 93, Issue 3, 362-367, 1948
Copyright © 1948 by American Society for Pharmacology and Experimental Therapeutics

THE TOXICITY AND MUSCULAR EFFECT OF d-TUBOCURARINE COMBINED WITH beta-ERYTHROIDINE, MYANESIN OR EVIPAL

F. M. Berger M. D.1 and R. P. Schwartz M. D.1

1 The Department of Pediatrics and The Department of Surgery, Division of Orthopedics, The University of Rochester School of Medicine and Dentistry, Rochester 7, New York

d-Tubocurarine and beta-erythroidine administered jointly show potentiation in effective and lethal doses. The margin of safety of the mixture of the drugs is smaller than that of d-tubocurarine administered alone. The combined administration of d-tubocurarine and myanesin showed slight potentiation in lethal doses and incomplete additive action in effective doses. d-Tubocurarine and evipal showed incomplete additive action in both effective and lethal doses. The significance of the findings is discussed.

Submitted on March 31, 1948






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Copyright © 1948 by the American Society for Pharmacology and Experimental Therapeutics.